Put two systems on neighbouring channels and interference leaks between them two ways, and both matter. The transmitter is not perfectly clean, so some of its power falls in the adjacent channel, set by its adjacent-channel leakage ratio, ACLR. The receiver is not perfectly selective, so a strong signal in the adjacent channel is not fully rejected, set by its adjacent-channel selectivity, ACS, also called adjacent-channel rejection, ACR. A frequency plan that looks at only one of the two can be wrong by a wide margin, because the two add and the worse one usually dominates.
The noIM₃ Adjacent Channel Rejection Calculator is the interference utility for that work, written for a systems integrator rather than a filter designer. The ACLR and ACS are datasheet and standards figures, not synthesised, and the output is framed as the numbers that decide a frequency plan. The Receiver ACR/ACS mode refers the adjacent interferer into the wanted channel as the adjacent level less the ACS, computes the carrier-to-interference ratio, and reports the margin over the protection ratio, the highest tolerable adjacent level, and the ACS a receiver would need to just pass. The Transmitter ACLR mode reports the power a transmitter leaks into the adjacent channel in dBm, watts, and as a fraction of the transmit power.
The Combined ACIR mode is the systems-integration heart. The transmitter leakage and the receiver selectivity add on a power basis, so the total adjacent-channel isolation is ACIR = −10·log₁₀(10^(−ACLR/10) + 10^(−ACS/10)), which sits just below whichever contributor is worse. The Coexistence mode turns that into a deployment answer: for an interferer and a victim on adjacent channels, the effective interference is the transmit power less the coupling loss and the ACIR, and the tool reports the margin, the coupling loss the pair needs, and the extra isolation to make up with separation or filtering.